Programme

Sunday 9th of November

   
12:00 – 14:00 Registration
14:00 – 14:20 Welcome session/house keeping
14:20 – 15:35 Workshop 1 - Developments in Protein Expression.
Chair: Alexey Rak
14:20 – 14:45 Accelerating protein production workflows
Jawahar Sudhamsu, Genentech
14:45 – 15:10 MemProtMD, protein binder toolbox for SLCs
David Sauer, University of Oxford
15:10 – 15:35 Advances in cell free expression systems
Michael Chen, Nuclera
15:35 – 16:05 Coffee and Exhibition Viewing 
16:05 – 17:20 Workshop 2 - Cryo-EM Data Workflows.
Chair: Chun-wa Chung
16:05 – 16:30 CCP-EM Doppio: An Image to Model cryoEM/T Processing Suite and Plans to Accelerate SPA in Relion
Tom Burnley, CCPEM
16:30 – 16:55 Towards Automating cryo-EM data analysis: Insights from processing data at scale
Robert Engelmeier, Cryocloud
16:55 – 17:20 Enabling high throughput Electron Cryo-microscopy for Structure-based Design
Amir Apelbaum, Astex
17:30 – 19:00 Registration/Free Time/ Poster Setup
19:30 – 21:30 Exhibition/Poster

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Monday 10th of November

 09:00 – 09:15  Welcome session/house keeping
 09:15 – 10:30  Session 1 - Expanding Target Space.
 Chair: Helena Kaeck
 09:15 – 09:40  Expanding ligase and target space of Targeted Protein degradation (TPD)
 Martin Schroeder, Novartis
 09:40 – 10:05  Optimisation of a kinetic mass spectrometry assay to accelerate covalent drug   discovery for intractable targets.
 Alexander Milbradt, AstraZeneca
 10:05 – 10:30  Targeting IDPs: a challenge and opportunity in drug development
 Peter Tompa, VIB
 10:30 – 11:00  Coffee and Exhibition Viewing
 11:00 – 12:00  Session 2 - Cryo-EM: New Tools and Applications.
 Chair: Alexey Rak
 11:00 – 11:25  Apolipoproteins A-IV fibrils: Structural diagnosis of mixed cardiac amyloidosis
 Shintaro Aibara, AstraZeneca
 11:25 – 12:00  A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small   Proteins for Drug Discovery
 Camille Samson, Sanofi
 12:00 – 12:45  Gold Sponsor talks
 12:00 – 12:10
 12:10 – 12:20
 12:20 – 12:30
 12:30 – 12:40		  NUVISAN ICB GmbH
 Desert Scientific Software
 leadXpro
 Refeyn Ltd
 12:40 – 14:10  Lunch and Exhibition Viewing 
 14:10 – 15:00  Session 3 - AI/ML in Structural Biology I.
 Chair: David Brown
 14:10 – 14:35  AI-application in construct engineering to enable cryo-EM based SBDD for targets   that were once thought impossible
 Huixian Wu, Pfizer
 14:35 – 15:00  OpenBind: generating foundational structural biology data to power the next era of   AI/ML for drug discovery
 Elizabeth Shotton, Diamond Light Source
 15:00 – 15:30  Coffee and Exhibition Viewing
 15:30 – 16:45  Session 4 - Emerging Technologies.
 Chair: Chun-wa Chung
 15:30 – 15:55  Small molecule discovery provides new insights into ion transport regulation of the   neuronal potassium chloride cotransporter KCC2, a potential target for epileptic   disorders
 Katharina Duerr, University of Oxford
 15:55 – 16:20  The cryo-EM structure of human GPR75: insights into ECL2-mediated activation  
 Rebecca Ebenhoch, Boehringer Ingelheim
 16:20 – 16:45  Miniaturised sample preparation for cryo-EM using microfluidics
 Rouslan Efremov, VIB Brussels
 16:45 – 17:30  Plenary Talk Emerging technologies and their applications– Alexey Rak, Sanofi
 19:00 – 22:00  Dinner in Safran Zunft/Free Evening

 

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Tuesday 11th of November

 

 09:00 – 09:05   House Keeping
 09:05 – 10:20  Session 5 - AI/ML in Structural Biology II.
 Chair: Djordje Musil
 09:05 – 09:30  AI Workflows to Accelerate Research (Drug Discovery)
 Tobias Ploetz, Merck KGaA
 09:30 – 09:55  Using Protein Design and AI/Machine Learning to Facilitate Structure-Based Drug   Design
 Peggy Stolt-Bergner, Boeringer Ingelheim
 09:55 – 10:20  Improving protein-ligand co-folding predictions by leveraging data from multiple   pharma companies
 Robin Roehm, Apheris
 10:20 – 10:50  Coffee and Exhibition Viewing
 10:50 – 12:05  Session 6 - Biologics.
 Chair: Andreas Kuglstatter
 10:50 – 11:15  Large molecule structure-based design: past, present and future
 Guy Georges, Roche
 11:15 – 11:40  Structural investigation of an extracellular nanobody in complex with the muscarinic-   acetylcholine receptor M2R
 Nicholas Vance, Crelux
 11:40 – 12:05  Development of a novel antibody-based oral factor VIIIa-mimetic drug candidate –   Inno8
 Eva Johansson, NovoNordisk
 12:05 – 12:45  Gold Sponsor Talks
 12:05 – 12:15
 12:15 – 12:25
 12:25 – 12:35
 12:35 – 12:45		  CryoCloud
 Cube Biotech
 ThermoFisher Scientific
 Biortus
 12:45 – 12:55  Poster Prizes
 12:55 – 14:15  Lunch and Exhibition Viewing
 14:15 – 15:30  Session 7 - Case Studies.
 Chair: Christian Wiesmann 
 14:15 – 14:40  Direct targeting of a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor   by fragment-based drug discovery
 Wolfgang Jahnke, Novartis
 14:40 – 15:05  Insights from structures guiding the development of WRN inhibitors targeting specific   ligand-induced conformations
 Apirat Chaikuad, GSK
 15:05 – 15:30  Exploring the mechanisms of Nicotinamide N-Methyl Transferase inhibition
 Patrik Johansson, AstraZeneca
 15:30 – 15:45  Closing Remarks